Cycloauration of pyridyl sulfonamides
نویسندگان
چکیده
منابع مشابه
Allergy to sulfonamides.
CLINICAL VIGNETTE A 48-year-old man was referred to our clinic with high-grade intermittent fever for 8 days and a generalized rash for 3 days. Threeweeks before presentation, the patient had been started on 5 mg/d prednisolone, 50 mg of diclofenac twice daily, 20 mg/d omeprazole, and 2 g/d of sulfasalazine for symptomatic ankylosing spondylitis. During the initial evaluation, he was febrile (3...
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In October 1955 three reports in the Deutsche Medizinische Wochenschrift' described a new sulfonamide derivative possessing the ability when given by mouth to reduce normal blood sugar values to subnormal, and elevated blood and urine sugar values in diabetes to normal. Reduction of normoglycemia had been shown with other sulfonamide derivatives as early as 1942," but the application to therapy...
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The sulfonamides and their structurally related derivatives, such as the sulfamates and sulfamides, possess the general formula A-SO2NHR, in which the functional group is either directly bound to an aromatic, heterocyclic, aliphatic, or sugar scaffold (of type A), or appended to such a scaffold via a heteroatom, most frequently oxygen or nitrogen (leading thus to sulfamates and sulfamides, resp...
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The diuretic sulfonamides furosemid (FLFur) and hydrochlorothiazid (H2Hyt) were used as ligands in zinc complexes. Spectroscopic data indicate that in [(HFur)Zn(H 2 0 )2 ]C1 0 4 and (HFur)2Zn the furosemid ligand is bound to zinc via its carboxylate and amine functions while (Fur)Zn(NH3)2 is a coordination polymer with Zn-carboxylate and Zn-sulfonimide coordination. A structure determination sh...
متن کاملResistance to trimethoprim and sulfonamides.
Sulfonamides and trimethoprim have been used for many decades as efficient and inexpensive antibacterial agents for animals and man. Resistance to both has, however, spread extensively and rapidly. This is mainly due to the horizontal spread of resistance genes, expressing drug-insensitive variants of the target enzymes dihydropteroate synthase and dihydrofolate reductase, for sulfonamide and t...
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ژورنال
عنوان ژورنال: Dalton Transactions
سال: 2008
ISSN: 1477-9226,1477-9234
DOI: 10.1039/b803835j